To persistently annoy, irritate, or bother someone in a way that feels deeply personal or invasive. Describes something that affects someone more than surface-level irritation.
This phrase dates to the 1890s and uses the metaphor of something penetrating beneath the surface of the skin, suggesting deeper irritation than mere surface annoyance. It may have origins in the literal discomfort of parasites or splinters under the skin. The expression emphasizes how some irritations feel invasive and hard to ignore.
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