Abasic

/eɪˈbeɪsɪk/ adjective

Definition

In biochemistry, relating to or describing a DNA molecule that is missing a nitrogenous base (one of the chemical building blocks of DNA).

Etymology

From 'a-' (without) + 'basic' (relating to bases), specifically the nitrogenous bases that form the rungs of the DNA ladder. This is specialized scientific terminology from molecular biology.

Kelly Says

An abasic site in DNA is like a missing rung on the DNA ladder—it doesn't stop the ladder from existing, but it creates a weak point that cells have special 'repair crews' to fix. Cancer can sometimes result from accumulating too many of these damaged sites.

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