A rare medical condition where the brain develops without the normal ridges and grooves on its surface, resulting in severe intellectual disability.
From Greek 'a-' (without) and 'gyrus' (ridge or fold), coined in the early 20th century as medical terminology expanded to describe neurological conditions. The term combines ancient Greek roots with modern medical naming conventions.
Your brain has all those wrinkles for a reason—they massively increase surface area so you can have billions of neurons. People with agyria have a brain that's like a smooth tennis ball instead of a walnut, which is why it's so serious. It's one of those conditions that shows how tiny details in brain development absolutely matter for everything we can do.
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