A class of chemical compounds that combine amino groups with quinoline structures, famous for being the active ingredients in antimalarial drugs like chloroquine and hydroxychloroquine.
From amino- + quinoline (quin from quinine + -oline, a chemical suffix). The quinoline ring itself is based on quinine, the natural alkaloid from cinchona bark discovered by Spanish conquistadors in Peru.
Hydroxychloroquine, an aminoquinoline drug that's been used for malaria since the 1950s, unexpectedly became one of the most controversial medicines during COVID-19, showing how old drugs can suddenly become relevant in new ways.
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