Opposed to or hostile toward mysticism and mystical interpretation; favoring rational or material explanations.
From anti- (against) + mystical (relating to mystery and spiritual truth), with the -al suffix from Latin. Mystical comes from mysticism, which derives from Greek mysterion meaning 'secret rite or doctrine.'
The rise of antimystical philosophy in the 17th century didn't actually eliminate mysticism—instead, it created a permanent tension where spiritual seekers and rational thinkers have been talking past each other for 400 years.
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