The quality or state of opposing mysticism and mystical thinking; the character of being rational and non-mystical.
From antimystical (opposed to mysticism) + -ness (noun suffix). This compound follows English morphology by stacking suffixes to create an abstract noun from an adjective.
The antimysticalness of modern science is its greatest strength and strangest weakness—it's unleashed incredible knowledge but sometimes leaves humans feeling oddly disconnected from wonder, even as scientific discoveries reveal the universe is stranger than any mystic ever imagined.
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