In chemistry, having two substituent groups (different atoms or groups attached to a main molecular structure).
From bi- (two) + substituted (from substitute, Latin substituere meaning 'to put in place of'). Standard chemical nomenclature developed in the 19th century.
A bisubstituted benzene ring might have a chlorine atom on one side and a nitro group on the other—chemists can predict how differently these molecules will behave just from knowing their positions, which is why the exact placement matters for drug design.
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