To confuse, perplex, or bewilder someone; to bamboozle or confound.
American dialectal term, likely a blend of 'bump' or 'bum' (meaning to affect negatively) and 'fuzzle' (to confuse), possibly influenced by 'befuddle.' Common in 19th-century American English.
Bumfuzzle is pure American frontier slang that somehow never caught on nationally, despite being wonderfully expressive—it appears in Mark Twain's writings and suggests confusion with physical force, like your brain getting bumped around.
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