An atypical antidepressant that blocks dopamine and norepinephrine reuptake, used to treat depression and smoking cessation. Unlike other antidepressants, it typically increases energy and libido rather than causing sedation.
Developed by GlaxoSmithKline in the 1960s, the name reflects its chemical structure as an aminoketone. Originally marketed as Wellbutrin for depression and Zyban for smoking cessation.
Bupropion is the 'energizing' antidepressant that actually helps with weight loss and smoking cessation because it affects dopamine - the brain's reward chemical. It's the only antidepressant that doesn't cause sexual side effects, making it popular for patients who experience these problems with SSRIs, but it can trigger seizures in vulnerable individuals.
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