To produce harsh, discordant sounds; to make something sound unpleasant or noisy.
From 'cacophony' + the verb-forming suffix '-ize' (to make or become); '-ize' is an extremely productive English suffix that can turn almost any noun into a verb.
The suffix '-ize' is so common in English that we barely notice it, but it's actually a Greek feature—English grabbed it and now uses it to create verbs from everything ('weaponize,' 'prioritize,' 'optimize').
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