An archaic or poetic form of 'create' or an exclamation expressing surprise or mild oath.
From Old French 'creer' or Latin 'creare' meaning to make or create. The short form 'cre' appears in archaic literature as both a verb and an interjection.
Old English and Middle English had dozens of shortened exclamation forms ('zounds' from 'God's wounds,' 'odds bodkins' from 'God's body')—'cre' shows how medieval writers played with language to hint at religious oaths without saying them directly.
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