In a cursed, damned, or unfortunate manner; used to express that something happened in a way that was wretched or afflicted by bad luck.
From 'cursed' (past participle of 'curse') plus the adverbial suffix '-ly.' This adverb form has been in English since at least the 16th century but remains relatively uncommon in modern usage.
This is one of those perfectly correct but rarely-used words—you could say 'he was cursedly unlucky,' but modern speakers prefer 'he was dreadfully unlucky,' showing how adverb preferences shift even when old forms remain valid.
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