An archaic or obsolete form meaning to heal, cure, or remedy (extremely rare variant).
A variant or inflected form of 'discure', possibly from Middle English or Late Latin. The '-en' suffix may represent an alternative conjugation or tense marker from older English grammar systems.
This appears to be such a specialized variant that almost no modern dictionaries include it—it might be a dialectal form or a scribal variant from medieval manuscripts. It's the kind of word that makes etymologists excited because it reveals how language branched in different directions.
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