The state of being made unable or incapable; the act or process of depriving someone of ability or power.
From disenable + -ment (a suffix that creates nouns describing states or results of actions). This noun form emphasizes the process or condition of being rendered incapable.
Medieval and Renaissance texts used this abstract noun to discuss how poverty, illness, or servitude could cause the 'disenablement' of entire populations—it's a philosophical word for systemic inability.
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