American spelling: to make something disorganized or confused; to break down or destroy the organization of something; to throw into disorder.
From dis- (reversal) + organize (from organizer, based on organ and the French organiser). The American -ize spelling reflects the Greek-Latin suffix -izo.
Words like 'disorganize' show English's love of reversals—we can take almost any adjective, make it a verb, then add 'dis-' to describe the opposite action.
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