Having had liquid removed or emptied out; feeling extremely tired or depleted of energy.
From Old English 'drehnian' meaning 'to strain,' related to 'dry.' The word originally referred to the physical removal of water or other liquids, but by the 16th century had developed the metaphorical sense of depletion of energy or resources.
The phrase 'brain drain' uses this word metaphorically to describe the emigration of educated people from one country to another, treating human capital like a liquid resource that can be depleted. Interestingly, many languages have similar water-based metaphors for exhaustion, suggesting a universal human connection between physical and mental depletion.
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