to make into or as if into an island; to isolate or separate something from surroundings.
From en- (prefix meaning 'to cause to be') + isle (from Old French isle, from Latin insula meaning 'island'). The word emerged in Middle English to describe the process of creating island-like isolation.
This word perfectly captures the paradox of modern life—we're constantly 'enisling' ourselves with technology, creating digital islands even while physically surrounded by people. Shakespeare and other Renaissance writers used this metaphor to describe emotional isolation.
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