Causing fatigue or exhaustion; tiring, wearisome, or tedious.
From 'fatigue' + '-some' suffix (causing, tending to). A rare English formation from the 1700s-1800s, using the productive '-some' suffix to mean 'causing fatigue.'
Words ending in '-some' (like 'troublesome' or 'tiresome') create a sense of something being inherently annoying—'fatiguesome' is that rare word for a task that drains your energy just thinking about it. It's delightfully specific but almost entirely unused today.
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