To treat something as worthless or to hold it in very low regard; to not care at all about something.
From Latin 'flocci' (a lock of wool, something trivial) and 'pendere' (to weigh, to consider), literally meaning 'to weigh as wool.' The phrase 'flocci non facio' meant 'I care not a wisp of wool' in classical Latin, expressing complete indifference.
This is one of the longest words ever made from a single Latin phrase—Victorian scholars loved it so much they turned an entire expression of dismissal into one word! It appears in the famous anatomical term 'pneumonoultramicroscopicsilicovolcanoconiosis' as inspiration for how long words could get.
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