Extremely troubled or made ill by feelings of guilt; experiencing such intense guilt that it affects your physical or mental health.
From guilt + sick (Old English seoc, meaning ill or troubled). This compound combines the emotion of guilt with physical illness to express overwhelming guilt that manifests as sickness.
Guiltsick perfectly captures something psychologists call psychosomatic illness—guilt that's so intense it makes you physically sick—which shows how powerful emotions can literally affect our bodies in ways traditional medicine once didn't understand.
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