To become or cause someone to become physically or mentally tired. As a noun (different meaning), it is the rubber ring around a wheel that touches the ground.
The verb comes from Old English 'tēorian' meaning 'to fail, become weary.' The noun 'tire' is a shortened form of 'attire,' once used for the iron rim of a wheel, later for rubber. These two words have different origins but ended up with the same spelling.
When you say 'I’m tired' and 'my car needs new tires,' you’re actually using two unrelated words that just happen to meet in spelling. One is about weariness, the other about equipment. English often hides these double lives under one simple form.
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