An atypical antidepressant that blocks serotonin reuptake and certain serotonin receptors, commonly used off-label as a sleep aid due to its sedating properties. Also treats depression and anxiety disorders.
Developed by Angelini Research Laboratories in the 1960s, the name derives from its chemical classification as a triazolopyridine derivative. The '-one' suffix indicates its ketone-containing chemical structure.
Trazodone is prescribed more often for sleep than for depression because it's one of the few non-addictive sleep medications available. However, it can cause priapism - a painful, prolonged erection that requires emergency treatment - which is why male patients need to be warned about this rare but serious side effect.
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