In a way that makes someone feel physically uneasy, nervous, or lacking ease and relaxation.
Formed from 'uncomfortable' (un- + comfortable) with the -ly adverbial suffix. The root 'comfortable' comes from Latin 'comfortare' meaning to strengthen or make strong.
The prefix 'un-' is one of English's most productive word-builders—you can add it to almost any adjective to flip its meaning, which is why we have so many 'un-' words!
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