Not subject to regulation, restraint, or management. Lacking proper control or discipline.
From un- 'not' + controlled, from Old French contrôler 'to check accounts', later meaning 'to regulate'. The prefix un- negates the sense of regulation or management.
In medical research, 'uncontrolled studies' lack control groups for comparison, making them much less reliable than controlled trials. Many promising treatments fail when subjected to proper controlled testing.
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