A chemical reaction in which an aryl group (a hydrocarbon structure derived from aromatic compounds) is added to a molecule.
From 'aryl' (from aromatic hydrocarbon) plus '-ation' (suffix forming nouns of action). The term emerged in chemistry in the early 20th century as synthetic organic chemistry advanced.
Arylation reactions are absolutely crucial in pharmaceutical manufacturing—most modern drugs are made by arylating various molecular scaffolds, and chemists have spent decades developing better ways to do this, which is why medicines that would have been impossible to make 50 years ago are now routine.
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