Worthy of being despised; contemptible or deserving of scorn.
From despise (from Old French despire, Latin despicere 'to look down on') + -able. The suffix -able makes it mean 'capable of being' or 'worthy of being' despised.
This word is essentially Shakespeare's favorite insult—check out how many times he calls characters 'despicable' in his plays, which had almost the same meaning!
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