An enzyme that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate, a key reaction in cellular energy production.
From 'enol' + '-ase' (enzyme suffix), named because it works with enol-containing compounds in the glycolysis pathway, coined in the early 20th century.
Enolase is so essential to life that it's found in almost every living organism unchanged for billions of years—it's one of the most 'ancient' and conserved enzymes, making it a molecular fossil of early life.
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