In a manner related to or affecting the stomach or digestive system; from a digestive perspective.
From gut (stomach and digestive organs) plus -wise suffix meaning 'in the manner or direction of,' creating an adverb.
The -wise suffix was extremely productive in Middle English, allowing speakers to create adverbs meaning 'in this direction' or 'in this way'—we still use it in 'likewise,' 'clockwise,' and 'lengthwise.'
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