To leave or run away quickly, usually when you're in trouble or told to go away.
Possibly from Yiddish 'shram' or from a blend of 'scramble' and other words. Became popular slang in early 20th century America, especially in crime and comedy contexts.
Scram became iconic in 1930s gangster movies and cartoons—it's the word Mickey Mouse would yell at Pete, and it somehow captures both urgency and playfulness at the same time.
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