People who talk a lot or enjoy talking; those who speak about something, or sometimes people who are known for their conversation ability.
From talk (of imitative origin, possibly related to Old English and Germanic roots) + -er (agent suffix meaning 'one who does') + -s (plural). Straightforward formation meaning 'those who talk.'
Every language has this pattern—the -er suffix is so productive that English speakers can instantly turn almost any verb into 'one who does that thing,' which is why talkers feels natural even though it's a simple combination.
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