To accustom someone to something unpleasant or harmful through repeated exposure; to harden or toughen.
Variant spelling of 'inure', from Middle English 'enuren', possibly from Old French 'enurer'. The 'in-' prefix combined with 'ure' (to practice) suggests habituating through practice. The 'e-' variant emerged as an alternative spelling.
Athletes use this principle constantly—they enure their bodies to pain and exhaustion through training, which is why professional marathon runners can push through distances that would hospitalize untrained people.
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