To make fretful or worried; to cause to become anxious or restless.
From 'fret' plus '-ize' (suffix meaning to cause to be or to make). This follows the common English pattern of forming verbs from adjectives or nouns, allowing the quality of fretfulness to be applied as an action.
The '-ize' suffix is English's word-factory tool—it can turn almost any adjective into a verb meaning 'to make' that quality, so fretize means 'to make fretful,' just like dramatize means 'to make dramatic!'
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